{"id":2754,"date":"2025-06-11T16:49:04","date_gmt":"2025-06-11T11:49:04","guid":{"rendered":"https:\/\/youdigital.pk\/en\/?p=2754"},"modified":"2025-06-11T14:27:00","modified_gmt":"2025-06-11T09:27:00","slug":"bowel-cancer-cells-shape-shifting-breakthrough","status":"publish","type":"post","link":"https:\/\/youdigital.pk\/en\/2025\/06\/11\/bowel-cancer-cells-shape-shifting-breakthrough","title":{"rendered":"Bowel Cancer Cells&#8217; Shape-Shifting Breakthrough"},"content":{"rendered":"<p data-start=\"143\" data-end=\"583\"><strong>ISLAMABAD: Scientists have made a major breakthrough in understanding how aggressive bowel cancer spreads in the body.<\/strong><\/p>\n<p data-start=\"143\" data-end=\"583\">The research shows that bowel cancer cells can transform into skin or muscle-like cells, helping them become more resilient and spread more easily.<\/p>\n<p data-start=\"143\" data-end=\"583\">This discovery could lead to new treatments that prevent cancer from metastasizing and improve survival rates, especially as cases in younger adults rise globally.<\/p>\n<h4 data-start=\"585\" data-end=\"629\">Cellular Plasticity Drives Metastasis<\/h4>\n<p data-start=\"630\" data-end=\"1106\">The study, led by Cancer Research UK Scotland Centre and the University of Edinburgh, found that cancer cells lose their original identity, a process called cellular plasticity.<\/p>\n<p data-start=\"630\" data-end=\"1106\">Instead of remaining typical bowel cells, they start to resemble squamous cells (skin cells) or muscle cells, which are tougher and can survive harsher conditions.<\/p>\n<p data-start=\"630\" data-end=\"1106\">This adaptation allows the cancer to invade other organs, making treatment more difficult and reducing patient survival chances.<\/p>\n<h4 data-start=\"1108\" data-end=\"1145\">Gene Link to Aggressive Cancer<\/h4>\n<p data-start=\"1146\" data-end=\"1462\">The researchers also identified a key gene, <em data-start=\"1190\" data-end=\"1196\">Atrx<\/em>, linked to this aggressive behavior.<\/p>\n<p data-start=\"1146\" data-end=\"1462\">When this gene is lost or mutated, tumors are more likely to spread from the bowel to the liver, lymph nodes, and other areas.<\/p>\n<p data-start=\"1146\" data-end=\"1462\">This gene\u2019s role offers a potential target for new therapies aimed at stopping cancer\u2019s spread.<\/p>\n<p data-start=\"1464\" data-end=\"1777\">Bowel cancer is the second leading cause of cancer deaths in the UK, with thousands diagnosed every year.<\/p>\n<p data-start=\"1464\" data-end=\"1777\">Early-onset bowel cancer is rising, particularly among people aged 25-49, raising global concern.<br data-start=\"1669\" data-end=\"1672\" \/>This discovery provides hope for better treatments that can stop the deadly progression of the disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ISLAMABAD: Scientists have made a major breakthrough in understanding how aggressive bowel cancer spreads in the body. The research shows that bowel cancer cells can transform into skin or muscle-like cells, helping them become more resilient and spread more easily. This discovery could lead to new treatments that prevent cancer from metastasizing and improve survival &hellip;<\/p>\n","protected":false},"author":6,"featured_media":2755,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[1381,1382,1383],"class_list":["post-2754","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-bowel-cancer","tag-cancer-research","tag-metastasis"],"_links":{"self":[{"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/posts\/2754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/comments?post=2754"}],"version-history":[{"count":1,"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/posts\/2754\/revisions"}],"predecessor-version":[{"id":2756,"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/posts\/2754\/revisions\/2756"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/media\/2755"}],"wp:attachment":[{"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/media?parent=2754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/categories?post=2754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/youdigital.pk\/en\/wp-json\/wp\/v2\/tags?post=2754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}